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Your Position: Home > Activin RIIA

Activin RIIA

Brief Information

Name:Activin receptor type-2A
Target Synonym:Activin receptor type IIA,ACTR-IIA,ACTRIIA,ACVR2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
ACA-H5243 Human / Cynomolgus Human / Cynomolgus Activin RIIA / ACVR2A Protein, His Tag (MALS & SPR verified)
ACA-H5243-structure
ACA-H5243-sds
ACA-M52H3 Mouse Mouse Activin RIIA / ACVR2A Protein, His Tag (SPR & HPLC verified)
ACA-M52H3-structure
ACA-M52H3-sds
ACA-M52H3-hplc
ACA-H82Q3 Human / Cynomolgus Biotinylated Human / Cynomolgus Activin RIIA Protein, His,Avitag™
ACA-H82Q3-structure
ACA-H82Q3-sds
ACA-H5269 Human / Cynomolgus Human / Cynomolgus Activin RIIA / ACVR2A Protein, Fc Tag
ACA-H5269-structure
ACA-H5269-sds
ACRO Quality

Part of Bioactivity data

ACA-H5269-ELISA
Activin RIIA ELISA

Immobilized Human Activin A, premium grade (Cat. No. ACA-H421b) at 5 μg/mL (100 μL/well) can bind Human ACVR2A, Fc Tag (Cat. No. ACA-H5269) with a linear range of 0.4-25 ng/mL (QC tested).

Protocol

Customer Reviews

Synonym Name

Activin receptor type IIA,ACTRIIA

Background

Activin receptor type-2A (ACVR2A) is also known as Activin receptor type IIA, ACTR-IIA, ACTRIIA and ACVR2,which is single-pass type I membrane protein. ACVR2A belongs to the protein kinase superfamily,TKL Ser/Thr protein kinase family and TGFB receptor subfamily.On ligand binding,ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.ACVR2A is Receptor for activin A, activin B and inhibin A as well. Several type I I activin receptors have been identified and bind to different activins with different affinities.

Clinical and Translational Updates

Related Molecule

Activin A

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